Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familial Premature Ovarian Failure.
BACKGROUND: The human condition known as Premature Ovarian Failure (POF) is characterized by loss of ovarian function before the age of 40.A majority of POF cases are sporadic, but 10-15% are familial, suggesting a genetic origin of the disease.Although several causal mutations have been identified, Phytoceramides the etiology of POF is still unkno